Brilliant physicist roommates Leonard and Sheldon meet their new neighbor Penny, who begins showing them that as much as they know about science, they know little about actual living.
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Leonard volunteers to sign for a package in an attempt to make a good impression on Penny, but when he enlists Sheldon for help, his attempt at chivalry goes terribly awry.
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Sheldon's getting fired forces him to explore what life has to offer outside physics, leaving Leonard to take drastic action to snap his friend out of his funk.
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Fearing he's wasting his time on Penny, Leonard ends up making a connection with Leslie. Meanwhile, Sheldon frets over a change to his hamburger routine.
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Sheldon and Amy's super asymmetry theory is proven by two physicists, Dr. Pemberton and Dr. Campbell from Chicago, who then try to kick Amy off the Nobel nomination. Bernadette has a big success at work and Penny's going to be a part of it.
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Sheldon is thrilled to help Bernadette and Howard navigate bureaucratic paperwork, until he discovers they are breaking the law. Leonard is disappointed when his friends exclude him from a scientific project.
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Penny tries to seduce an abstaining Leonard to ruin his "donation" for her ex-boyfriend, Zack, and his wife, Marissa. Howard, Bernadette, Anu and Raj turn to Raj's canceled bachelor party into a couple's trip aboard the "vomit comet".
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The gang finds out Wil Wheaton hosts a celebrity Dungeons and Dragons game involving William Shatner, Joe Manganiello, Kareem Abdul-Jabbar and Kevin Smith. Deception and betrayal are the path to make it to the one open seat.
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Penny and Bernadette go to San Diego for a pharmaceutical sales convention, leaving Howard in charge of the kids. Sheldon finds a book on experimenting on kids, and the guys plus Amy make a day of it.
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Pemberton and Campbell charm America on a publicity tour, so Sheldon and Amy bring Nobel laureates Kip Thorne, George Smoot, and Frances Arnold to their side. Halley's fear of the dark leads to conflict for Howard, Bernadette and Stuart.
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Amy has a meltdown due to the pressure associated with winning a Nobel Prize. Raj and Howard try to relive the good old days after Howard buys a scooter that looks like the one he had years ago.
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Raj is worried people won't take him seriously in his own field after publishing a paper that suggests he may have discovered alien life. Leonard wants to be the principal investigator on a plasma physics study.
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Kripke has proof that Dr. Pemberton plagiarized his thesis, and Sheldon and Amy aren't sure they should turn him in or not. Howard is surprised to learn that Bernie wasn't the only waitress at the Cheesecake Factory who had a crush on him.
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Leonard is pleasantly surprised when Beverly comes to visit and she's genuinely kind to him, until he finds out the real reason she's there. Denise and Stuart overstay their welcome at the Wolowitz house.
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In the series finale, Bernadette and Howard leave their kids for the first time; Penny and Leonard try to keep a secret; Sheldon and Amy stick together; and Raj makes a new friend, as the gang travels together into an uncharted future.
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